The human diet and dietary patterns are closely linked to the health status. High-calorie Western-style diets have increasingly come under scrutiny as their caloric load and composition contribute to the development of non-communicable diseases, such as diabetes, cancer, obesity, and cardiovascular disorders. On the other hand, calorie-reduced and health-promoting diets have shown promising results in […]
Exercise in a Pill: The Latest on Exercise-Mimetics
There is increasing evidence that an active lifestyle benefits both body and brain. However, not everyone may be able to exercise due to disease, injury or aging-related frailty. Identification of cellular targets activated by physical activity may lead to the development of new compounds that can, to some extent, mimic systemic and central effects of […]
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Cell Signal. Author manuscript; available in PMC 2013 May 1. Published in final edited form as: Cell Signal. 2012 May; 24(5): 981–990. Published online 2012 Jan 20. doi: 10.1016/j.cellsig.2012.01.008 PMCID: PMC3454471 NIHMSID: NIHMS351530 PMID: 22286106 Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling Paul D. Ray, Bo-Wen Huang, and Yoshiaki Tsuji* Author information […]
NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD+ can directly and indirectly influence many key cellular functions, including metabolic pathways, DNA repair, chromatin remodelling, cellular senescence and immune cell function. […]
U.S. Military to Test NAD+ Anti-Aging Pill
The U.S. military says it is months away from launching clinical trials of a pill designed to block or reduce many degenerative effects of aging—an oral treatment that a leading researcher in the field says is better than nothing while questioning how effective it will ultimately prove. U.S. Special Operations Command (SOCOM)—which develops and employs […]
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