Category Mimetics

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise Svenia Schnyder and Christoph Handschin* Author information Copyright and License information Disclaimer Biozentrum, Div. of Pharmacology/Neurobiology, University of Basel, Basel, Switzerland *Correspondence: Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland, Phone: +41 61 2672378, hc.sabinu@nihcsdnah.hpotsirhc Copyright notice The publisher’s final edited version of this […]

Hormesis is a term used by toxicologists to refer to a biphasic dose response to an environmental agent characterized by a low dose stimulation or beneficial effect and a high dose inhibitory or toxic effect. In the fields of biology and medicine hormesis is defined as an adaptive response of cells and organisms to a […]

The human diet and dietary patterns are closely linked to the health status. High-calorie Western-style diets have increasingly come under scrutiny as their caloric load and composition contribute to the development of non-communicable diseases, such as diabetes, cancer, obesity, and cardiovascular disorders. On the other hand, calorie-reduced and health-promoting diets have shown promising results in […]

There is increasing evidence that an active lifestyle benefits both body and brain. However, not everyone may be able to exercise due to disease, injury or aging-related frailty. Identification of cellular targets activated by physical activity may lead to the development of new compounds that can, to some extent, mimic systemic and central effects of […]

Exercise and diet are powerful interventions to prevent and ameliorate various pathologies. The development of pharmacological agents that confer exercise- or caloric restriction-like phenotypic effects is thus an appealing therapeutic strategy in diseases or even when used as life-style and longevity drugs. Such so-called exercise or caloric restriction “mimetics” have so far mostly been described […]